It is increasingly recognized that including polyphenols and other active molecules found in fruits and vegetables in our daily diet promotes good health.
Our molecular extracts make it possible to target specific health applications where the consumption of polyphenols and other bioactive molecules has shown measurable benefits.
Antioxidant effects :
Our tests have shown a linear correlation between the antioxidant properties and the total polyphenols found in our molecular extracts.
The following graph illustrates that the more concentrated the polyphenols in our molecular extracts, the greater their ORAC value (measured in µM/g).
Antioxidant activity is very important as it reduces oxidative stress and eliminates all free radicals from the body.
A blood concentration of approximately 0.036 mg of polyphenols per litre of blood seems to be the required dosage to alleviate oxidative stress. Studies on the bioavailability of our polyphenol molecular extracts have shown that 2% of the ingested dose is found in blood plasma. OniCan is the exception, with an absorption rate closer to 10%. The following table summarizes the required dosage of each extract to obtain the desired level of antioxidants.
|Molecular extract||Grade||Polyphenol concentration||Required dosage||ORAC value|
Urinary tract infections :
Our UroPhenol products (Advantage, Select, and Pure) are an excellent option for preventing urinary tract infections (UTIs) as they contain fully standardized proanthocyanidins (PACs). PACs inhibit the adhesion of E. coli (the bacteria that causes the majority of UTIs in humans), therefore preventing the onset of infection.
The PACs found in UroPhenol are primarily A-type, which are responsible for the anti-adhesion properties observed in the countless studies published on cranberry products and the prevention of UTIs. What’s more, our comparative tests have shown that UroPhenol 15% is 125 times more effective than cranberry fruit powders or dry juice concentrates.
The effective dose for preventing UTIs is 36 mg of cranberry PACs using the BL-DMAC method. Moreover, this is the dose (measured by this method) required in order to be marketed in the medical devices category in Europe.
Our UroPhenol product line offers flexible options for clients who want to use this ingredient to develop products. The Advantage grade, with 1% PACs, is ideal for developing products packaged in pouches to be diluted in water as UroPhenol is entirely water soluble. The Select and Pure grades, equally water soluble, can be used to manufacture capsules or tablets. The Pure grade is especially useful when it must be mixed with other active ingredients, such as D Mannose or probiotics.
Cognitive decline :
With today’s aging population, preventing cognitive decline in seniors has become a growing concern. Cognitive decline is closely linked to the degeneration of neurons exposed to oxidative stress. Studies have shown that a diet high in polyphenols found in fruit may slow down, or even reverse, this process.
We have already seen that NeuroPhenol (a combination of wild blueberry and grape seed polyphenols) prevents cognitive decline in rats. This study led us and our partners at the Université de Bordeaux to begin a study on humans to reproduce these results by looking specifically at the effects on concentration, short-term memory, and the ability to makes plans. Results will be obtained by the end of 2014.
Oral health :
Studies have also been conducted on our CranCan and BlueCan molecular extracts and the prevention of tooth decay and gum disease. It is estimated that nearly 40% of the United States population suffers from mild to severe periodontal disease. In collaboration with Dr. Daniel Grenier’s laboratory at Université Laval, Nutra Canada has shown on recognized models the efficacy of CranCan and BlueCan in inhibiting the formation of Fusobacterium nucleatum, an oral biofilm bacterium that contributes to the development of microbial flora that cause cavities and gum disease. A concentration of 75 µg/mL (CranCan) or 100 µg/mL (BlueCan) is required to be effective.
Our molecular extracts are entirely water soluble, making them ideal for developing liquid products, such as mouthwash, to which they can be added. Other possibilities include chewing gum or a film that dissolves under the tongue since the most concentrated forms of CranCan and BlueCan take up very little space.
|Molecular extract||Grade||Polyphenol concentration||Required dosage|
Sports nutrition :
Our SpiCan molecular extract is made of spinach and is rich in nitrate. Nitrates are beneficial to the vasodilation (widening of the blood vessels), which lets more oxygen-rich blood reach your heart during physical exertion and improves recovery. SpiCan is 2.5% nitrates. When ingested, nitrates are absorbed and metabolized by the body as nitric oxide (NO), which modulates blood pressure and regulates extracellular fluid homeostasis. A dosage of 1 g of SpiCan is equivalent to 30 g of fresh spinach.
Eye health :
Carotenoids are a class of molecules found in fruits and certain vegetables. Numerous studies on the effects of carotenoids on eye health have shown them to be effective at penetrating the cerebrospinal barrier. Results suggest that lutein (structurally similar to vitamin A) could play a role in preventing age-related macular degeneration. A dosage of 1 g of SpiCan contains 0.15% lutein, the equivalent of 227 g of fresh spinach.
Blood sugar management
Antioxidant polyphenols found in fruits may play a key role in reducing oxidative stress. Moreover, polyphenols found in fruits such as cranberries, strawberries, and wild blueberries seem to significantly improve insulin resistance among obese individuals showing early signs of resistance. A clinical trial has shown that a daily dosage of 1,000 mg of NutraPhenol (our new purified cranberry and patented Authentique Orléans strawberry extract) improved insulin sensitivity among participants by 13.6% over a 6-week period.
Sulforaphane found in broccoli, once absorbed by the body, plays a role in stimulating phase II detoxification enzymes and is a powerful antioxidant.
BroCan is a molecular extract made from broccoli florets with standardized glucoraphanin, the metabolic precursor of sulforaphane. Once ingested, glucoraphanin is converted to sulforaphane by gut micorflora and then absorbed by the body. BroCan contains 1.5% glucoraphanin, and therefore 1 g contains the equivalent of 30 g of fresh broccoli.