As our population ages, it is normal that the incidence of certain degenerative diseases increases. Often the first sign of these diseases in aging individuals is a decline in cognitive functions such as concentration, short-term memory, and the ability to make plans.
The observed indications of cognitive decline are not fully understood, however, certain studies show that a diet high in polyphenols found in fruits and vegetables may help reduce, and even reverse, neuronal degeneration associated with aging. Studies conducted on animals and humans have shown that consuming as little as 1.8 mg of polyphenols found in wild blueberries can improve cognitive function.
NeuroPhenol is made from a wild blueberry and grape seed extract. Nutra Canada jointly participated to a preliminary study on animals showing that NeuroPhenol significantly reduces the decline in cognitive functions in aging mice compared to the control group (NutriNeuro). Based on these results, Nutra Canada, in partnership with the ‘Consortium NeuroPhenols’, is attempting to reproduce these results in a study on humans (NEUROPHENOL STUDY). This trial, which will recruit 200 patients, is currently underway and slated for completion at the beginning of 2015.
NeuroPhenol, available in a powder, is a unique composition from wild blueberry and grape seed.
- Industrial partners:
The SMEs (Small and medium-sized enterprise) Activ’Inside (Libourne, FR) and Nutra Canada (Champlain, CA) will develop active plant ingredients (fruits partly provided by Fruits d’Or, Québec, CA) that will be directly tested and objectified in adapted formulations. These formulations will be developed by Atrium Innovations (Québec City, CA) for products intended for human and by SPF-Diana (Elven, FR), for products intended for pets. These two industrial groups enjoy a leading position in their respective markets.
- Academic partners:
The mixed research unit (UMR) Nutrineuro (National Institute for Agricultural Research [INRA] and University of Bordeaux) specialized in nutrition and neurobiology, the Institute of Nutrition and Functional Foods (INAF, Laval University, Québec City, CA), the National Institute for Scientific Research (INRS-IAF, Laval, CA) and the National Veterinary School ONIRIS (Nantes, FR), will bring their scientific expertise in human and animal nutrition as well as neurobiology.
- Transfer cell:
Polyphenols Biotech (Bordeaux, FR; agency attached to the Institute of Sciences of Vine and Wine, ISVV) will ensure to meet the analytical needs of the project. It will also work on the screening of health activities in cellular model.
Neurophenols project is co-financed in France by the “Fonds Unique Interministériel” (FUI) which supports research and development projects of the competitiveness clusters; by the European Regional Development Fund (ERDF) and by several local authorities: Aquitaine, Bretagne and Pays de la Loire regional councils; general council of Morbihan and urban community of Vannes. The project is co-accredited by the competitiveness clusters Valorial and Agrimip Sud Ouest Innovation.
On the Canadian side, Neurophenols project is co-financed by the Government of Québec and the City of Québec.